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. 2019 Aug 7;11(8):1131. doi: 10.3390/cancers11081131

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of ISL treatment on E2-induced mouse uterine myometrium growth. (A) Schematic design of the in vivo mice uterine myometrium hyperplasia model. (B) Mice body weights at the beginning and the end of the study. After eight weeks treatment, mice were sacrificed, and serum (C) estradiol and (D) progesterone concentrations were measured using ELISA. (E) The uterus was photographed, (F) the weights of uteri were measured and (G) normalized to whole body weight. Scale bar = 1 cm. Data are represented as means ± SEM (n = 5 each group). * p < 0.05, ** p < 0.01 compared with the control group. ^# p < 0.05 compared with the E2-treated group.