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. 2019 Aug 9;11(8):1145. doi: 10.3390/cancers11081145

Figure 5.

Figure 5

Immunoistochemical evaluation of B cell infiltration in (a) KRAS WT (60% of infiltration) and (b) mutated cases (0% infiltration), respectively (magnification: 20×) Moreover, cases in LUAD-TCGA with low B cell infiltration have a significantly worse overall survival than those with higher levels (Figure 6a). Interestingly, in the real-life cohort we observed the same results stratifying for presence/absence of KRAS mutation, with mutated patients having a poor outcome (Figure 6b). Moreover, mutated patients in cluster 2 have a worse overall survival than cluster 1 KRAS WT cases (Figure 6c).