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. 2019 Aug 16;11(8):1195. doi: 10.3390/cancers11081195

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Kaplan–Meier (KM) curves for HSPB1 (gene name of heat shock protein 27 (HSP27)) in the overall survival of various cancers. Gastric cancer, lung cancer, hepatocellular carcinoma, breast cancer, clear cell renal carcinoma, and rectum adenocarcinoma show high survival rates associated with low HSPB1 expression. p-values were calculated using the log-rank test. The Hazard Ratio (HR) is the ratio of the hazard rates corresponding to the conditions described by two levels of an explanatory variable (HR > 1 was considered a higher hazard of death from the HSPB1-High group). An independent univariate survival analysis of overall survival (OS) was analyzed based on a merged data set from the Kaplan–Meier Plotter [76]. Data were derived from http://kmplot.com/analysis/ and survival curves were drawn using PRISM software [77].