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. 2019 Aug 16;11(8):1195. doi: 10.3390/cancers11081195

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Strategies of heat shock protein 27 (HSP27) inhibitors. (1) Three small molecule inhibitors (Brivudine (RP101), Quercetin, and cross-linker) bind directly to the HSP27 protein and inhibit the activity of the HSP27 protein. (2) Peptide aptamers (PA11 and PA50) bind directly to the HSP27 protein and inhibit oligomerization or dimerization. (3) Antisense oligonucleotide (OGX-427) binds to HSP27 mRNA and prevents translation of the HSP27 protein. As a result, the amount of HSP27 protein is reduced.