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. 2019 Jul 24;8(8):769. doi: 10.3390/cells8080769

Figure 6.

Figure 6

Multiplex analysis of ctDNA extracted from plasma of patient 18, 19 and 20 at T0 time point. (A) Cy3 fluorescence images of the triplex analysis (with all the reporters for KRAS and NRAS codon 12-13 and BRAF) of ctDNA extracted from plasma of patients 18, 19 and 20 at T0 time point. The barcode probes corresponding to KRAS G12D (patients 18 and 20) and G12S (patient 19) are highlighted. (B) Schematic representation of the spotted barcode probe array. Q61H1 c.183A>C, Q61H2 c.183A>T. (C) Cy3 fluorescence image of the duplex analysis (with all the reporters for KRAS codon 61 and 146) of ctDNA extracted from plasma of patient 18 at T0 time-point. Only the barcode probes corresponding to KRAS codon 61 and 146 wild-type sequences are shown.