Table 3.
Comparison of liquid biopsy results from patients’ enrolment at T1 and T2 and clinical evaluation.
| Sample ID | Microarray | ddPCR Mutated Allele % | Clinical Evaluation RECIST Classification |
|---|---|---|---|
| Pz 1 T0 Pz 1 T1 Pz 1 T2 |
G12D + G12R G12D wt |
G12D = 0.033%; G12R = 0.95% G12D = 0.4 %; G12R = 0.22% G12D = 0%; G12R = 0.25% |
>> PRSD |
| Pz 3 T0 Pz 3 T1 Pz 3 T2 |
wt wt wt |
- - - |
>>PR CR |
| Pz 4 T0 Pz 4 T1 Pz 4 T2 |
wt wt wt |
- - - |
>>PR CR |
| Pz 5 T0 Pz 5 T1 |
wt wt |
- - |
SD |
| Pz 7 T0 Pz 7 T1 Pz 7 T2 |
G12C G12C wt |
G12C = 32.3% G12C = 0.17% G12C = 0% |
>>PR CR |
| Pz 10 T0 Pz 10 T1 |
wt wt |
- - |
SD |
| Pz 11 T0 Pz 11 T1 |
wt wt |
- - |
SD |
| Pz 13 T0 Pz 13 T1 Pz 13 T2 |
A146T wt A146T |
A146T = 20% A146T = 1% A146T = 3.3% |
>>PR PD |
| Pz 14 T0 Pz 14 T2 |
G13D G13D |
G13D = 1.3% G13D = 0.22% |
>>PR |
| Pz 17 T0 Pz 17 T1 |
wt wt |
- - |
SD |
| Pz 19 T0 Pz 19 T1 |
G12S G12S |
G12S = 17.7% G12S = 14% |
PD |
| Pz 20 T0 Pz 20 T1 |
G12D G12D |
G12D = 3.7% G12D = 0.3% |
PR |
PR = Partial Response, SD = Stable Disease, CR = Complete Response; PD = Progression Disease.