Table 2.
Mice | SCID | Rag-1/Rag-2 Knock Out Mice |
---|---|---|
Chromosome | Chr.16 | Chr.11 p13 |
Mutated gene | Prkdc | Recombination-activation gene-1/-2 |
Mutation | Natural mutant | Homologous recombination |
Immunological phenotype | Deficiency of mature B and T lymphocytes NK cells are normal |
Deficiency of mature B and T lymphocytes NK cells were normal |
Radiation sensitivity | Sensitive (Lethal dose < 3 Gy) |
Normal (Lethal dose 9 Gy) |
Leakiness | Leaky | None |
Rag = recombination activating gene.