Table 2.

Comparison of SCID and Rag-1/Rag-2 mutation.

Mice	SCID	Rag-1/Rag-2 Knock Out Mice
Chromosome	Chr.16	Chr.11 p13
Mutated gene	Prkdc	Recombination-activation gene-1/-2
Mutation	Natural mutant	Homologous recombination
Immunological phenotype	Deficiency of mature B and T lymphocytes NK cells are normal	Deficiency of mature B and T lymphocytes NK cells were normal
Radiation sensitivity	Sensitive (Lethal dose < 3 Gy)	Normal (Lethal dose 9 Gy)
Leakiness	Leaky	None

Rag = recombination activating gene.