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. 2019 Aug 12;8(8):879. doi: 10.3390/cells8080879

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of iPla2β deficiency during MCD feeding on BA (bile acids) contents in liver, ileum, and enterohepatic circulation. Female WT and iPla2β^−/− mice were fed with chow or MCD diet for 5 weeks. BA profiles of samples were determined by LC-MS/MS. BA profiles in (A) liver, (B) ileum, (C) bile, (D) portal vein serum, and (E) vena cava serum. (F) Total BA contents in liver, bile, ileum, portal vein serum, and vena cava serum. (G) BA classified as primary BA, secondary BA, Fxr agonists, Fxr antagonists, free BA, and conjugated BA. (H) Liver cholesterol levels. Data are mean ± SEM, N = 5–7; * p < 0.05; ** p < 0.01 between indicated groups.