Table 1.
Patient characteristics at baseline.
| A | B | C | ||
|---|---|---|---|---|
| Total | HLA-E*01:03 Carrier# | HLA-E*01:03 Non-Carrier | p-Value B vs. C | |
| Donor | N = 278 | N = 211 | N = 67 | |
| Sex (men/women) | 115/163 | 89/122 | 26/41 | 0.67 a |
| Age (y) ±SD | 51.41 ± 10.03 | 51.99 ± 10.06 | 43.30 ± 9.83 | 0.10 b |
| Recipient | N = 278 | N = 198 | N = 80 | |
| Sex (men/women) | 162/116 | 116/82 | 46/34 | 0.87 a |
| Age (y) ±SD | 41.06 ± 15.43 | 40.46 ± 15.42 | 42.53 ± 15.47 | 0.32 b |
| KTx Related Variables | ||||
| HLA A, B mismatches, mean ± SD | 1.97 ± 1.14 | 1.83 ± 1.1 | 2.31 ± 1.17 | 0.002 **b |
| HLA-DR mismatch, mean ± SD | 1.12 ± 0.62 | 1.09 ± 0.60 | 1.19 ± 0.66 | 0.22 b |
| Panel of Antibodies (%) | ||||
| 0% | 244 | 172 | 72 | 0.55 a |
| 1–10% | 14 | 9 | 5 | 0.55 a |
| 10–50% | 14 | 12 | 2 | 0.36 a |
| >50% | 6 | 5 | 1 | 0.68 a |
| Cold ischemia time, median, in minutes (range) | 134.99 ± 48.90 | 136.07 ± 48.63 | 131.32 ± 48.86 | 0.57 b |
| Warm ischemia time, median, in minutes (range) | 19.97 ± 6.87 | 19.38 ± 5.84 | 21.46 ± 8.83 | 0.057 b |
| Immunosuppressive Therapy | ||||
| ATG-based induction therapy, yes/no | 13/265 | 9/189 | 4/76 | 1 a |
| CNI administration, yes/no | 278/0 | 198/0 | 80/0 | nd |
| MMF co-administration, yes/no | 260/18 | 189/9 | 75/5 | 0.55 a |
| Steroid co-administration, yes/no | 278/0 | 198/0 | 80/0 | nd |
| PyVAN and CMV | ||||
| PyVAN, yes/no | 11/267 | 11/187 | 0/80 | 0.031 *a |
| CMV positive recipient | 159/119 | 116/82 | 43/37 | 0.46 a |
| CMV positive donor | 177/101 | 128/70 | 49/31 | 0.59 a |
| CMV Infection, yes/no | 38/240 | 32/166 | 6/74 | 0.057 a |
| PyVAN and CMV infection, yes/no | 3/275 | 3/195 | 0/80 | 0.27 a |
| PyVAN or CMV infection vs. no PyVAN and no CMV infection | 46/232 | 40/158 | 6/74 | 0.01 a |
y: years; HLA: human leukocyte antigen; ATG: antithymocyte globulin; CNI: calcineurin inhibitor; MMF: mycophenolate mofetil; KTx: kidney transplant; PyVAN: BK polyomavirus associated nephropathy; CMV: cytomegalovirus; nd: not determined; SD: standard deviation. a Fisher’s exact test; b Mann–Whitney U test; # HLA E*01:03 carrier: HLA E*01:03/01:03 and HLA E*01:03/01:01genotype; HLA E*01:03 non-carrier: HLA E*01:01/01:01 genotype. * p < 0.05, ** p < 0.01.