Table 7.
Genotype distribution of allele frequencies of HLA-E polymorphism in living-donor kidney transplant recipients (A) and corresponding donors (B) with respect to BK polyomavirus nephropathy (PyVAN).
|
(A) Recipient
HLA-E genotype |
PyVAN
N = 11 |
No PyVAN
N = 267 |
p-Value | OR | 95% CI |
| 01:03/01:03 | 3 (27.3%) | 61 (22.8%) | 0.73 | 1.26 | 0.33–4.92 |
| 01:01/01:03 | 8 (72.7%) | 126 (47.2%) | 0.10 | 2.98 | 0.77–11.50 |
| 01:01/01:01 | 0 (0%) | 80 (30%) | 0.025 * | 0.09 | 0.005–1.59 |
| Allele Frequencies | |||||
| 01:03 | 14 | 248 | 0.11 | 2.02 | 0.83–4.89 |
| 01:01 | 8 | 286 | |||
|
(B) Donor
HLA-E genotype |
PyVAN
N = 11 |
No PyVAN
N = 267 |
p-Value | OR | CI (95%) |
| 01:03/01:03 | 1 (9.1%) | 62 (23.2%) | 0.27 | 0.33 | 0.04–2.63 |
| 01:01/01:03 | 9 (81.8%) | 139 (52.1%) | 0.052 | 4.14 | 0.89–19.55 |
| 01:01/01:01 | 1 (9.1%) | 66 (24.7%) | 0.24 | 0.3 | 0.04–2.42 |
| Allele Frequencies | |||||
| 01:03 | 11 | 263 | 0.77 | 1.1 | 0.47–2.7 |
| 01:01 | 10 | 271 | |||
* p < 0.05.