Table 1.

Adipocytes regulate breast cancer via their metabolic substrates.

Metabolic Substrates		Released by White/Brite/Brown Adipocytes	Effect on BC Development	Effect on BC Cell Proliferation	Effect on BC Cell Invasion	References
Free fatty acids	Saturated; (n-6) fatty acids	White	Increase	Increase	Increase	[46,47,53,57,58,59]
	(n-3) fatty acids	White	Decrease	Decrease	Decrease	[43,45,49]
Lipids, Triglycerides		White	Increase	Increase	Increase	[61]
Cholesterol	Total	White	Increase	Increase	Increase	[60,62,63]
	HDL	White	Decrease	Decrease	Decrease	[44]
	LDL	White	Increase	Increase		[44]
	VLDL	White	Increase	Increase	Increase	[44]
	27-OHC	White	Decrease	Decrease		[41,53]
Exosome	mir- 3184-5p	White	-	Increase	Increase	[50]
	mir- 184c-3p	White	-	Decrease	Decrease	[50]
Proteases (MMP-9, MMP-11)		White	Increase	Increase	Increase	[74,75,76]

Note: 27-Hydroxycholesterol, 27-OHC; matrix metalloproteinase-9, MMP-9; high-density lipoprotein, HDL; low-density lipoprotein, LDL; very-low-density lipoprotein, VLDL; breast cancer, BC.