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. 2019 Aug 11;8(8):873. doi: 10.3390/cells8080873

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Upstream regulators and signaling cascades linked to the hNgb protein interactors in a non-stress condition. (a) The top predicted upstream regulators of hNgb-linked pathways: nucleoside diphosphate kinase 3 (NME3), fibroblast growth factor 2 (FGF2), cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1), transforming growth factor-alpha (TGFA), DNA-binding protein inhibitor ID-1 (ID1), transcriptional activator Myb (MYB), RE1-silencing transcription factor (REST), insulin-like growth factor I (IGF1), and epidermal growth factor receptor (EGFR). (b) The ‘cell death and survival, cellular development, cellular growth, and proliferation’ pathway network shows the highest connectivity with hNgb-protein interactions. The latter are indicated as green in the figure. (c) Vimentin does not only interact with hNgb but has been identified as the hNgb-interactor with the highest number of predicted connections itself. These provide an indirect link with/influence on hNgb functions.