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. 2019 Aug 16;8(8):909. doi: 10.3390/cells8080909

Figure 1.

Figure 1

Rab proteins and transport pathways involved in neurodegenerative diseases. Schematic representation of a neuron and a post-synaptic terminal showing key Rab proteins and the trafficking pathways that they regulate. The Rab-dependent processes that are altered in neurodegenerative diseases (indicated in red) are highlighted. AD: Alzheimer’s disease, PD: Parkinson’s disease; ALS: amyotrophic lateral sclerosis; CMT2B: Charcot–Marie–Tooth 2B; LRRK2: leucine-rich repeat kinase 2; NGF: nerve growth factor; TrkA: tropomyosin receptor kinase A; AMPA: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid.