(b)
Markers | Haplotype | Frequency | OR (T:U) | χ2 | p-Value | |
---|---|---|---|---|---|---|
Raw | Permuted | |||||
rs1565902-rs10001410-rs2122642 | CCC | 0.411 | 1.74 (74.1:42.5) | 8.5 | 0.004 | 0.021 |
a UCSC GRCh37/hg19 coordinates. Chr: Chromosome; HA: Heterozygous advantage; NIF: Number of informative families; FBAT: Family-based association test; OR: Odds ratio; T: Transmitted; UT: Untransmitted. Permuted p-values were obtained using 10,000 permutations as implemented in the HaploView’s ParentTDT algorithm [60]. All markers are intronic. Additional details on these markers are provided in Table S1.