Table 2.
Tract-based spatial statistics analysis of diffusion tensor and free-water imaging indices in patients with Parkinson’s disease and healthy controls.
| Modality | Contrast | Cluster Size | Anatomical Region | Peak t-Value | Peak MNI Coordinates (X, Y, Z) |
|---|---|---|---|---|---|
| Single-tensor DTI | |||||
| FA | HC > PD | 46483 | Bilateral ATR, CST, CgH, IFOF, ILF, SLF, UF, temporal part of the SLF, retrolenticular part of the IC, ACR, SCR, PCR, PTR, sagittal stratum, external capsule, tapatum; Lt-CCG; Rt-PLIC; fornix, forceps major and minor, genu, body and splenium of CC | 6.81 | 133, 124, 44 |
| MD | HC < PD | 39448 | Bilateral ATR, CST, IFOF, ILF, SLF, UF, temporal part of the SLF, ALIC, PLIC, retrolenticular part of the IC, ACR, SCR, PCR, PTR, sagittal stratum, external capsule, SFOF, tapatum; genu, body and splenium of CC, fornix and forceps major and minor | 5.9 | 113, 160, 76 |
| AD | HC < PD | 8520 | Bilateral ATR, CST, IFOF, UF, ALIC, ACR, SCR, external capsule, SFOF; Lt-PLIC; Rt-SLF, PCR, retrolenticular part of the IC, fornix; genu and body of CC, forceps minor | 5.49 | 113, 160, 76 |
| RD | HC < PD | 54131 | Bilateral ATR, CST, CgH, IFOF, ILF, SLF, UF, temporal part of the SLF, medial lemniscus, ICP, SCP, ALIC, PLIC, retrolenticular part of the IC, ACR, SCR, PCR, PTR, sagittal stratum, external capsule, SFOF, tapatum; Lt-CCG; genu, body and splenium of CC, fornix, forceps major and minor and MCP | 5.95 | 121, 106, 64 |
| Bi-tensor FW imaging | |||||
| FAT | HC > PD | 22185 | Bilateral ATR, CST, IFOF, ILF, SLF, ACR, SCR, PCR, external capsule; Lt-CCG, UF, retrolenticular part of the IC, PTR, sagittal stratum; forceps major and minor, genu, body and splenium of CC, fornix | 5.37 | 45, 125, 47 |
| MDT | HC < PD | 18356 | Bilateral ATR, CST, IFOF, SLF, UF, ALIC, PLIC, ACR, SCR, external capsule, SFOF; Lt-CCG, retrolenticular part of the IC, PCR; forceps minor, genu, body and splenium of CC; fornix | 5.73 | 119, 94, 120 |
| ADT | HC < PD | 11610 | Bilateral ATR, CST, IFOF, UF, ALIC, PLIC, retrolenticular part of the IC, ACR, SCR, PCR, external capsule, SFOF; Rt- SLF; genu, body and splenium of the CC and forceps minor | 5.52 | 80, 158, 77 |
| RDT | HC < PD | 33504 | Bilateral ATR, CST, IFOF, ILF, SLF, UF, ALIC, PLIC, ACR, SCR, PCR, PTR, sagittal stratum, external capsule, SFOF; Lt-CCG; temporal part of the Rt-SLF, retrolenticular part of the IC, UF, tapatum; forceps major and minor, genu, body and splenium of CC, fornix | 5.64 | 143, 99, 99 |
| FW | HC < PD | 5716 | Bilateral ATR, CST, IFOF, ILF, SLF, SLF temporal part, SCR, PCR, PTR, tapatum; Lt-retrolenticular part of the IC, sagittal stratum; Rt-ACR; forceps major and minor, genu, body and splenium of CC, fornix | 5.45 | 89, 133, 74 |
Lt, left; Rt, right; ACR, anterior corona radiata; AD, axial diffusivity; ADT, free water-corrected axial diffusivity; ALIC, anterior limb of the internal capsule; ATR, anterior thalamic radiation; CC, corpus callosum, CCG, cingulum cingulate gyrus; CgH, cingulum hippocampus; CST, corticospinal tract; DTI, diffusion tensor imaging; FA, fractional anisotropy; FAT, free water-corrected fractional anisotropy; FW, free water; HC, healthy control; IC, internal capsule; IFOF, inferior fronto-occipital fasciculus; ILF, inferior longitudinal fasciculus; MD, mean diffusivity; MDT, free water-corrected mean diffusivity; MNI, Montreal Neurological Institute; PCR, posterior corona radiata; PD, Parkinson’s disease; PLIC, posterior limb of the internal capsule; PTR, posterior thalamic radiation; RD, radial diffusivity; RDT, free water-corrected radial diffusivity; SCR, superior corona radiata; SFOF, superior fronto-occipital fasciculus; SLF, superior longitudinal fasciculus; UF, uncinate fasciculus.