Table 4.
Gray-matter-based spatial statistics analysis of free-water imaging indices in patients with Parkinson’s disease and healthy controls.
| Modality | Contrast | Cluster Size | Anatomical Region | Peak t-Value | Peak MNI Coordinates (X, Y, Z) | |
|---|---|---|---|---|---|---|
| MDT | HC < PD | 4.9 | 38, 60, 46 | |||
| — | Frontal | — | ||||
| 42 | Temporal | Bilateral fusiform, Rt-entorhinal and temporal pole | ||||
| 43 | Parietal | Bilateral precuneus | ||||
| 23 | Occipital | Bilateral lingual | ||||
| 102 | Limbic and para-limbic | Bilateral isthmus cingulate and para-hippocampal; Rt-hippocampus | ||||
| 49 | Deep GM | Lt-thalamus; Rt-caudate and putamen | ||||
| ADT | HC < PD | 5.05 | 38, 60, 46 | |||
| — | Frontal | — | ||||
| 62 | Temporal | Bilateral fusiform; Rt-enthorinal, inferior temporal and temporal pole | ||||
| 53 | Parietal | Bilateral precuneus | ||||
| 27 | Occipital | Bilateral lingual | ||||
| 146 | Limbic and para-limbic | Bilateral isthmus cingulate, para-hippocampal and hippocampus; Rt-amygdala and accumbens | ||||
| 162 | Deep GM | Bilateral thalamus, caudate; Rt-putamen | ||||
| FW | HC < PD | 7.37 | 43, 46, 54 | |||
| 534 | Frontal | Bilateral lateral orbitofrontal, medial orbitofrontal, pars opercularis, pars orbitalis, pars triangularis, superior frontal, frontal pole and precentral; Rt-paracentral and rostral middle frontal | ||||
| 235 | Temporal | Bilateral fusiform and superior temporal; Lt-transverse temporal; Rt-entorhinal, fusiform, inferior temporal and temporal pole | ||||
| 132 | Parietal | Bilateral post-central, precuneus; Rt-supramarginal | ||||
| 47 | Occipital | Bilateral lingual; Lt-cuneus, lateral-occipital and pericalcarine | ||||
| 1106 | Limbic and para-limbic | Bilateral isthmus cingulate, caudal anterior cingulate, posterior cingulate, rostral anterior cingulate, insula, para-hippocampal, accumbens and hippocampus; Rt-amygdala | ||||
| 133 | Deep GM | Bilateral thalamus, caudate and putamen | ||||
Lt, left; Rt, right; ADT, free water-corrected axial diffusivity; FW, free water; GM, gray matter; HC, healthy controls; MDT, free water-corrected mean diffusivity; PD, Parkinson’s disease.