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. 2019 Aug 13;8(8):888. doi: 10.3390/cells8080888

Figure 4.

Figure 4

Cell fusion of cancer cells caused by heat stress and their fates. (A) Time-lapse images of MGC-803 cells; (A1) bipolar division, (A2) multipolar division, and (A3) cell apoptosis of MGC-803 cells after cell fusion induced by heat stress, scale bar: 50 μm. (B) Time-lapse images of MCF-7; (B1) bipolar division, (B2) multipolar division, and (B3) cell apoptosis of MCF-7 cells after cell fusion induced by heat stress, scale bar: 40 μm. (C) The cell fusion frequency of MGC-803 cells and their cell fates; (C1) the frequency of MGC-803 cells with cell fusion (mean values ± SD are shown from three independent experiments); (C2) MGC-803 cells fates with cell fusion; the ratios through the routes of bipolar divisions, multipolar divisions and cell apoptosis are 4:12:1 in the control group and 25:34:27 in the heat shock group of MGC-803 cells, respectively. (D) The cell fusion frequency of MCF-7 cells and their cell fates; (D1) the frequency of MCF-7 cells with cell fusion (mean values ± SD are shown from three independent experiments); (D2) MCF-7 cells fates with cell fusion; the ratios through the routes of bipolar divisions, multipolar divisions and cell apoptosis are 1:10:0 in the control and 7:31:29 in the heat shock group of MCF-7 cells, respectively. BP (bipolar), MP (multipolar), and AP (apoptosis). p-value < 0.05 was considered statistically significant, ***p < 0.001.