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. 2019 Aug 7;8(8):845. doi: 10.3390/cells8080845

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Established compounds and drug candidates evaluated for the treatment of NAFLD/NASH in clinical trial phase III. Pioglitazone (PPARγ agonist), vitamin E (antioxidant), pentoxifylline (anti-tumor-necrosis factor-α (TNF-α) agent), Obeticholic acid (farnesoid X receptor antagonist), cenicriviroc (CCR2/CCR5 inhibitor), elafibranor (PPARα/δ agonist), and selonsertib (ASK1 inhibitor) have different molecular targets. The different biological activities of the drugs point to the complexity of NAFLD/NASH, having a large variety of potential therapeutic drug targets. The depicted structures were generated with the open source molecule viewer Jmol using data deposited in the PubChem compound database with CIDs: 4829, 14985, 4740, 447715, 11285792, 9864881, and 71245288). For more details about the biological activity of each drug refer to [32].