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The use of female germline stem cells to overcome mtDNA disease. Female germline stem cells from a carrier of a mtDNA mutation or deletion can be depleted of their mtDNA and fused to an enucleated stem cell harboring unaffected (non-mutated or deleted) mtDNA from a donor source to generate a reconstructed female ‘cybrid’ germline stem cell. The cell can then be proliferated and cultured to the metaphase II stage in readiness for fertilization.
