Figure 3.

Inflammasome components can be directly visualized in zebrafish. (A) Transparent 2 days post-fertilization zebrafish larvae were challenged by previously described infection and inflammation conditions [29,70]. (B) Visualization of Asc speck formation in zebrafish macrophages infected with Mycobacterium marinum. (C) il1b reporter gene visualization upon Mycobacterium marinum infection. (D) il1b-producing leukocytes are recruited to the intestine of a zebrafish larvae in a model of Copper-induced intestinal inflammation.