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Steps in the NAE pathway. (1) Internalisation via clathrin-dependent or clathrin-independent mechanisms; (2) sorting at the early endosomal stage; (3) docking of NAE to the nuclear envelope; (4) fusion of NAE and the ONM; (5) translocation of the receptor from the ONM to the INM via the NPC; (6) extraction of the receptor from the INM membrane into the nucleoplasm.
