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. 2019 Aug 14;8(8):897. doi: 10.3390/cells8080897

Figure 6.

Figure 6

Parkin siRNA reverses the inhibitory effect of ATF4 on NLRP3 inflammasome activation. Representative Western blots showing the levels of NLRP3 protein, cleaved-caspase-1, cleaved-IL-1β and cleaved-IL-18 (B–F), and histograms showing the total ROS levels in the cortex (A). Error bars represent mean ± SD. (** p < 0.01, *** p < 0.001 and **** p< 0.0001 vs. indicated group). n = 5 in each group. MCAO, middle cerebral artery occlusion-reperfusion; GFP, green fluorescent protein; AAV, ATF4 overexpression adeno-associated virus; siRNA, small interfering RNA.