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. 2019 Aug 14;8(8):897. doi: 10.3390/cells8080897

Figure 7.

Figure 7

Mdivi-1 treatment impaired the effects of ATF4 on mitophagy activity and NLRP3 inflammasome activation. (A–C) No differences were observed in terms of ATF4 and parkin expression between the AAV + MCAO group and the mdivi-1 + AAV + MCAO group. Mdivi-1 treatment significantly impaired the inhibitory effects of ATF4 on TOM20 and COX4I1 expressions (D–F), NLRP3 inflammasome activation (H–L) and ROS production (G). Error bars represent mean ± SD. (* p < 0.05, ** p < 0.01, *** p < 0.001 and **** p< 0.0001 vs. indicated group). n = 5 in each group. MCAO, middle cerebral artery occlusion-reperfusion; GFP, green fluorescent protein; AAV, ATF4 overexpression adeno-associated virus; siRNA, small interfering RNA; mdivi-1, mitochondrial division inhibitor-1.