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View full-text article in PMC

. 2019 Aug 6;8(8):842. doi: 10.3390/cells8080842

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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DNA damage and repair capacity of PM and CR0 cells exposed to selected chemotherapeutic drugs. Three drugs were tested: (A,B) cisplatin, (C,D) gemcitabine, and (E,F) vinorelbine tartrate. Cells were treated with two selected concentrations of the above chemotherapeutic drugs for 48 h and their DNA damages were measured by comet assay directly or after a 24 h recovery period. Two DNA damage parameters are shown: (A,C,E) % tail DNA and (B,D,F) tail extent moment. Results shown are ratio over untreated PM-control. Error bars represent mean ± SD of three separate experiments. Dash line on the y-axis represents ratio value of PM-control at one.