Table 2.

Affinity constants for conjugates interacting with HER2.

Measurment	(ZHER2:2891)2–ABD–IAA	(ZHER2:2891)2–ABD–MC-DM1	(ZHER2:2891)2–ABD–E3–MC-DM1	(ZHER2:2891)2–ABD–E6–MC-DM1
ka (1/M·s)	3.0 × 105	7.9 × 104	5.6 × 104	5.5 × 104
kd (1/s)	9.6 × 10−5	1.4 × 10−4	1.3 × 10−4	1.5 × 10−4
KD (M)	3.2 × 10−10	1.7 × 10−9	2.4 × 10−9	2.8 × 10−9