Table 3.

Affinity constants for conjugates interacting with serum albumin.

Measurment	(ZHER2:2891)2–ABD–MC-DM1		(ZHER2:2891)2–ABD–E3–MC-DM1		(ZHER2:2891)2–ABD–E6–MC-DM1
	HSA	MSA	HSA	MSA	HSA	MSA
ka (1/M·s)	3.3 × 105	6.0 × 105	1.7 × 105	2.8 × 105	1.6 × 105	3.0 × 105
kd (1/s)	1.9 × 10−4	1.5 × 10−3	2.0 × 10−4	2.0 × 10−3	1.9 × 10−4	2.4 × 10−3
KD (M)	5.7 × 10−10	2.5 × 10−9	1.2 × 10−9	7.2×10−9	1.2 × 10−9	8.0 × 10−9