Skip to main content
. 2019 Aug 5;8(8):840. doi: 10.3390/cells8080840

Figure 2.

Figure 2

miRNAs in regulating cancer stem cells characteristics: miRNAs can both inhibit or stimulate the development and characteristic of CSCs such as the ability of self-renewal, sphere formation, and chemoresistance through targeting signaling pathways involved in their survival and proliferation. Many miRNAs were found to inhibit CSCs: miR-145 and miR-200c through inhibiting ADAM, miR-494 via BMI, miR-195-5p and miR-34 via inhibiting the Notch1 pathway, and miR-99a through inhibiting mammalian target of rapamycin (mTOR). Conversely, miR-519d and miR-128 inhibit CSCs via activating caspases. On the other hand, miRNAs can stimulate CSCs development: miR-19 and miR-501-5p through activating the wingless (WNT)/β-catenin signaling pathway; miR-21 and miR-221/222 via inhibiting phosphatase and tensin homolog (PTEN); and miR-483-5p, miR-196b-5p, and miR-494-3p through activating the Cyclin D1, STAT3, and Notch1 signaling pathways, respectively.