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. 2017 Dec 14;103(1):157–164. doi: 10.1002/JLB.5AB0217-070R

Figure 4.

Figure 4

Motolimod induces apoptosis of mMDSC, in part through FAS ligation. (A and B) Cell death percentage of mMDSC (A) and PBMCs (B) following treatment with PBS or motolimod in doses of 167 and 500 nM (n = 6 volunteer donors). (C and D) FAS expression in mMDSC population following treatment with PBS or 500 nM motolimod; (C) mean FL of FAS, n = 4 volunteer donors, and (D) representative overlay FLOW histograms of FAS expression (black, PBS; red, motolimod). (E and F) mMDSC percentage of PBMC (E) and cell death percentage of mMDSC (F) in PBS alone, with FAS blocking Ab or IgG1 isotype control, and in 500 nM motolimod alone, with FAS blocking Ab or IgG1 isotype control. Lines are the means of the experimental groups. *P < 0.05; **P < 0.01; ***P < 0.001