Table 3.

Patients Requiring Upward Lansoprazole Dose Adjustments^*

	Prior to increasing dose				Increased effective dose
Patient	Dose ( mg)†	Acid output (meq/hr)‡	Time taking lansoprazole (months)§	Reason for increase¶	Dose (mg)**	Acid output (meq/hr)††
1	60QD	12.4	6	Poor control, peptic symptoms	75QD	3.9
6	120QD	7.8	3	Peptic symptoms	60BID	4.1
8‡‡	60QD	10.0	3	Poor control	60BID	6.8
9§§	60QD	10.0	12	Poor control	60BID	2.1
18¶¶	75QD	4.8–18	3	Peptic symptoms	120QD	6.1

^*Abbreviations: QD = 24 hourly; BID = 12 hourly.

^†Effective dose at prior evaluation.

^‡Acid output immediately prior to requiting upward adjustment of lansoprazole dose.

^§Duration of therapy with lansoprazole at time of requiring upward adjustment.

^¶Reason dose adjusted upwards as per study design.

^**Effective dose following upward titration of lansoprazole.

^††Acid output following effective upward titration (higher of two values).

^‡‡Patient with widely metastatic disease and hemorrhagic liver metastases who continued to have peptic symptoms that were finally controlled with a 60-rag BID dose.

^§§Patient with MEN-I syndrome who required multiple incremental increases in dose for effective acid control in spite of lack of symptoms.

^¶¶patient who required multiple increases over a two-week period postoperatively with continued symptoms and repeat acid output controls on 90–105 mg QD of up to 18.1 meq/hr.