Figure 9.

Overview of the differential activation of the yeast multidrug system. a, hydrogen peroxide most sensitively activates Stb5 and the Snq2 transporter. b, menadione targets mainly Pdr1, but also Stb5, with Pdr5 as the most sensitively up-regulated transporter. c, citrinin activates transcription mainly through Pdr1, but also through Yrr1 with less efficiency. Snq2 and Pdr5 are induced with comparable sensitivities. d, ochratoxin A efficiently activates Yrr1 and the Snq2 transporter, however with less sensitivity than Pdr1 and the Pdr5 transporter.