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Bimodal regulation of sGC maturation by HSP90 in mammalian cells. When HSP90 binds to apo-sGCβ, it drives heme insertion into apo-sGCβ while also preventing its premature interaction with sGCα to form a heme-free, nonfunctional sGC heterodimer. Once heme insertion is complete, HSP90 dissociates from sGCβ, and this allows it to partner with sGCα to form a mature and functional sGC heterodimer.
