Figure 11.

Architecture of RBP-Jκ, POU, and Rta-c motifs are similar in the ORF50AS/K-bZIP (A), Mta (B), and ORF50 (C) distal promoters. Established or predicted cis-regulatory elements are shown by rectangles. The arrows on the thick line in A indicate positions of DE transcriptional start sites, with genomic coordinates listed below (8). Numbers below each RBP-Jκ motif (blue outlined Jk) indicate genomic coordinates and/or positions of motifs relative to transcriptional start sites. Horizontal arrows on DNA sequences indicate bp distances between motifs. D, summary of motif arrangements in Rta-transactivated promoters.