. 2019 Jul 11;294(35):12975–12991. doi: 10.1074/jbc.RA119.009830

Table 3.

Summary of kinetic modeling results

Simulation	Initial substrate^a	k_cat 11-deoxycorticosterone → corticosterone	k_cat corticosterone → 18-OH corticosterone	k_cat 18-OH corticosterone → aldosterone	Total Χ²^b
		s⁻¹	s⁻¹	s⁻¹
Initial simulations	11-DOC	0.55	0.25	0.050	13,600
Initial simulations	Cort		0.25	0.050	9600
Nonlinear regression fit to Fig. 8 model	11-DOC	4000 ± 495,000	0.70 ± 0.06	0.89 ± 0.15	1090
Nonlinear regression fit to Fig. 8 model	Cort		0.16 ± 0.02	0 (error not determined)	11,400
Nonlinear regression fit to Fig. 11 model	11-DOC	8000 ± 1,500,000	0.83 ± 0.07	13 ± 2	855
Nonlinear regression fit to Fig. 11 model	Cort		0.021 ± 0.02	5.4 ± 0.8	4978

^a 11-DOC = 11-deoxycorticosterone, and Cort = corticosterone.

^b X² = Σ_{i = 0}^{N − 1} ((y_i − y(x_i))/(σ_i))², with the standard deviation of each datum (σ_i) calculated from a double-exponential analytical fit to the transient for each compound in the data set as suggested by the software manual.