Skip to main content
. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Alcohol Clin Exp Res. 2019 Jul 16;43(9):1872–1886. doi: 10.1111/acer.14138

Figure 5. Mef2 mutants are resistant to ethanol sedation.

Figure 5.

(A and B) Ethanol sedation time courses of control flies (w1118 from BDSC) and the indicated Mef2 genotypes. Compound heterozygous Mef2 mutants Mef230−5/Mef265 (A) and Mef225−34/Mef265 (B) took longer to become sedated than flies heterozygous for these alleles. (C, D) ST50 values, derived from the data in panels A and B, respectively. There was a significant overall effect of Mef2 genotype on ST50 values (individual one-way ANOVAs; panel C, p<0.0001; panel D, p<0.0001; n=10). ST50 values were greater in Mef230−5/Mef265 (C) and Mef225−34/Mef265 (D) flies than in all other genotypes (*BMCs; panel C, p≤0.0003; panel D, p<0.0001).