Table 1. Candidate loci for follow-up in Drosophila.

37 human genes that reached p_gene<0.001 in human gene-based analyses from SRE GWAS study, whether they have any prior association with phenotypes of interest, and their subsequent highest rated fly ortholog(s) and corresponding DIOPT scores (listed orthologs have a DIOPT score ≥2).

Human Gene Symbol	Pgene	Previously associated human phenotypes of interest1	Drosophila Gene Symbol	DIOPT Score
MEF2B	0.0007412	Obsessive compulsive disorder	Mef2	4
APP	0.00050488	Cognition, neuropsychological tests, psychiatric status rating scales, psychotic disorders, tobacco use disorder	Appl	13
ATG5	0.00058657	Drug hypersensitivity, tobacco use disorder	Atg5	14
BORCS82	0.00050716	Tobacco use disorder, obsessive compulsive disorder	CG32590	13
BORCS8-MEF2B3	0.0007412	Tobacco use disorder	Mef2	4
GPD2	0.00028942	Fatty liver	Gpo1	13
ISL1	0.00038948	ADHD	tup	11
PCDH15	0.00012322	Alcoholism, tobacco use disorder	Cad99C	9
SFSWAP	0.00038044	Tobacco use disorder	su(w[a])	13
ANKRD6	0.00035656	N/A	dgo	4
ASPG	0.00081699	N/A	CG6428, CG8526	13
BHLHE40	0.00074851	N/A	Several	2
BIRC6	0.00053743	N/A	Bruce	15
C1QTNF5	0.00037187	N/A	N/A	N/A
DEPDC7	9.33E-05	N/A	N/A	N/A
DSG1	1.27E-05	N/A	N/A	N/A
EXOC1	2.97E-05	N/A	Sec3	14
IKZF1	0.00015571	N/A	N/A	N/A
LGSN	0.00034442	N/A	Gs1	2
LRRTM1	0.00031065	N/A	caps, trn	2
MFRP	0.00037187	N/A	CG42255	2
MMP17	0.00013157	N/A	Mmp2	7
PPP2R5E	0.00059389	N/A	wdb	13
PRAMEF11	0.00044431	N/A	N/A	N/A
PRB1	0.00036335	N/A	N/A	N/A
PSMD6	0.00062142	N/A	Rpn7	15
PXMP2	0.00076238	N/A	CG7970	7
SCGN	0.00078013	N/A	Cbp53E	8
SCN3B	0.00026792	N/A	N/A	N/A
SET	0.00023109	N/A	Set	13
STRN3	0.00051438	N/A	Cka	15
TCP11L1	0.00014072	N/A	CG16721	13
THAP2	0.00030577	N/A	CG14860	2
TMEM185B	0.00083227	N/A	CG14194	12
TMEM53	0.00069173	N/A	CG8245	14
USP2	0.00047617	N/A	Usp2	9
ZBTB44	5.54E-06	N/A	N/A	N/A

¹Primary resource was the Public Health Genomics Knowledge Base, supplemented by NCBI literature searches.

²This locus is also known as MEF2BNB.

³This locus is also known as MEF2BNB-MEF2B