Study design: Rats arrived in lab at postnatal day 21 (PND 21) and were differentially-reared in enriched (EC), isolated (IC), or standard (SC) conditions. Trichostatin A (TsA; 0.3 mg/kg, i.v.) or vehicle (10% DMSO in saline) injections were administered 30 minutes prior to operant sessions and continued through the final day of experimentation.
Abbreviations: AMP, amphetamine; DMSO, dimethyl sulfoxide; DSt, dorsal striatum; EC, enriched condition; IC, isolated condition; NAc, nucleus accumbens; SC, standard condition; TsA, Trichostatin A