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. Author manuscript; available in PMC: 2020 Feb 19.
Published in final edited form as: Nat Genet. 2019 Aug 19;51(9):1380–1388. doi: 10.1038/s41588-019-0479-7

Figure 6. HERV-H introduces new TAD boundaries during primate evolution.

Figure 6.

(a) A simplified tree of primate evolution with the copies of HERV-H annotated (left) and Hi-C interaction matrices of human ESCs, bonobo iPSCs, chimpanzee iPSCs, marmoset iPSCs and mouse ESCs are shown, along with DI scores at the syntenic regions to human HERV-H1 locus, HERV-H2 locus, and all top 50 transcribing HERV-Hs. The chimpanzee and bonobo syntenic regions are denoted with a star as they also contain HERV-H sequence. (b) Bar chart shows the percentage of HERV-H transcripts over all transcripts in the PSCs from each indicated species.

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