Table 1:

IC₅₀ of compounds 1a-1h for PSMA^α,β,γ.

Entry	R	IC50 (nM)	Entry	R	IC50 (nM)
1a		130.3±28.9	1f		555.5±79.3
1b		318.4±21.1	1g		45.7±6.7
1c		363.8±8.7	1h		128.0±8.4
1d		20.3±2.4	control	2-PMPA	523.5±84.0
1e		536.8±58.7

^αCell line in all cases is 22Rv1.

^βThe competitive binding compound is ⁶⁸Ga-PSMA-11.

^γCells were plated 48 h before testing (in triplicate). Various concentration (0.01–100000 nM) of compounds with 10 μCi of ⁶⁸Ga-PSMA-11 were added to cells and incubated for 1h. Cells were washed and lysed. A gamma counter was used to measure the bound fraction to the lysed cells.