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. Author manuscript; available in PMC: 2020 Mar 4.
Published in final edited form as: Curr Opin Genet Dev. 2019 Mar 4;54:7–11. doi: 10.1016/j.gde.2019.02.003

Figure 1:

Figure 1:

Patient-derived organoids and stromal cells, such as immune cells and cancer associated fibroblasts, can be isolated from small and large tissue samples. Organoids cultures can recapitulate clonal heterogeneity of the neoplastic tissue. the Molecular (DNA/RNA) and phenotypic (drug testing) characterization of mono- and co-culture systems can provide actionable clinical insights for cancer patients at all stages of the disease.