Fig. 1.

Schematic diagram of the study. We conducted a GWAS of the SQ-R (N = 51,564) and quantified SNP heritability $\left(h_{\mathrm{SNP}}^2\right)$, quantified genetic correlations with multiple phenotypes, and conducted polygenic score analyses. In addition, we conducted sex-stratified GWAS of the SQ-R, and investigated $h_{\mathrm{SNP}}^2$ within sex and genetic correlation between males and females. Finally, we investigated the clustering of all phenotypes that are genetically correlated with autism, and whether the social and the non-social phenotypes associated with autism are genetically correlated