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. 2019 Sep 3;9:12681. doi: 10.1038/s41598-019-49191-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MYL4+mosaicism by gender and disease. (A) Male subjects had more MYL4+ cells, independent of disease state (p = 8.66e-15). (B) In left ventricular segments, MYL4+ cells were increased in HCM compared to control tissues (TMAs 1&5). There were no control septal tissues to compare to the HCM cases on TMA4. The MYL4 residual is of a regression of sqrt(%MYL4+) cells adjusted for multiple measures per individual and effects of different TMAs, age, and sex.