Table 6.
Comparison of pharmacology for test compounds in the TRPV1 intracellular calcium assays. Data are expressed as the mean ± SEM of n = 3 individual concentration-response experiments.
| Name | Type | Fluo-4 pEC50 | GCaMP6s pEC50 |
|---|---|---|---|
| olvanil | agonist | 7.68 ± 0.41 | 7.84 ± 0.35 |
| arvanil | agonist | 6.76 ± 0.51 | 7.12 ± 0.38 |
| capsaicin | agonist | 7.16 ± 0.07 | 7.40 ± 0.08 |
| resiniferatoxin | agonist | 6.91 ± 0.32 | 7.00 ± 0.59 |
| N-oleoyl dopamine | agonist | 5.63 ± 0.13 | 5.67 ± 0.26 |
| dihydrocapsaicin | agonist | 7.21 ± 0.12 | 7.44 ± 0.16 |
| Fluo-4 pIC 50 | GCaMP6s pIC 50 | ||
| JNJ-17203212 | antagonist | 6.71 ± 0.22 | 6.49 ± 0.39 |
| BCTC | antagonist | 7.87 ± 0.09 | 8.10 ± 0.29 |
| SB-366791 | antagonist | 6.03 ± 0.21 | 5.84 ± 0.28 |
| ruthenium red | antagonist | 6.07 ± 0.13 | 6.92 ± 0.19 |
| AMG9810 | antagonist | 6.82 ± 0.07 | 6.76 ± 0.07 |
| JNJ-39729209 | antagonist | 7.18 ± 0.11 | 6.89 ± 0.14 |
| capsazepine | antagonist | 6.02 ± 0.12 | 5.65 ± 0.11 |