TABLE 2.

A summary of genetic adaptations reported in the Sherpa, and replication in other population(s) or species.

Genes name(s)	Sherpa		Other population(s) or species	Reference(s)
	Sample Size	Reference(s)
ACE	105	Droma et al., 2008	Elite European descent athletes	Montgomery et al., 1998; Jones et al., 2002
HIF-la	20	Suzuki et al., 2003	–	–
eNOS	105	Droma et al., 2006
EPAS1	105	Hanaoka et al., 2012	Tibetan	Beall et al., 2010; Simonson et al., 2010; Yi et al., 2010; Bigham et al., 2010; Peng et al., 2011; Wang et al., 2011; Xu et al., 2011
	51	Jeong et al., 2014	Deedu Mongolian	Xing et al., 2013
	582	Bhandari et al., 2016	Denisovan	Huerta-Sánchez et al., 2014
3.4 kb Copy Number Deletion-80 kb downstream of EPAS1	582	Bhandari et al., 2016	Tibetan	Lou et al., 2015
EGLN1	51	Jeong et al., 2014	Tibetan	Lorenzo, 2010; Simonson et al., 2010; Yi et al., 2010; Xiang et al., 2013; Lorenzo et al., 2014
	582	Bhandari et al., 2016	Andean	Bigham et al., 2009; Bigham et al., 2010
	111	Zhang et al., 2017	Daghestani	Pagani et al., 2012
PPARA	15	Horscroft et al., 2017	Tibetan	Simonson et al., 2010; Peng et al., 2011
		Kinota et al., 2018	(Amhara and Omotic) Ethiopian	Scheinfeldt et al., 2012
HYOUI/HMBS	51	Jeong et al., 2014	–	–
EPAS1, EGLN1, DLG1, MARCH8, CDCA7L, HEATR5B, EDAR, ZNF644, TTC24, TMEM247, OXR1, ALDH31	111	Zhang et al., 2017	–	–
NOS1	111	Zhang et al., 2017	Tibetan (GCH1), Andeans (NOS2)	Bigham et al., 2009; [opetwcitep]B20,B59[clotwcitep]Bigham et al., 2010; He et al., 2018
ANGPT1	111	Zhang et al., 2017	Tibetan and grey wolves of TAR, China	Jeansson et al., 2011; Wang et al., 2011
EPAS1, EGLN1, RP11-384F7.2 AC068633.1, ZNF53 2, HLA-DOB1/HLA-DPB1	10	Arciero et al., 2018	–	–
ANKH	10	Arciero et al., 2018	Pigs of TAR, China	Ai et al., 2014
GRB2	10	Arciero et al., 2018	Tibetans	Li et al., 2016
Polygeneic Adaptation {Gene subnetworks like the nested integrin associated pathways (i.e., Integrin β-1, Integral α6−β4 and Integrin involved in angiogenesis),CMYB and C-MYC transcription factor pathways}	31	Gnecchi-Ruscone et al., 2017, 2018	Tibetans	Gnecchi-Ruscone et al., 2018
EPAS1, EGLN1.CCDC141,PAPOLA, VRK1, C6orf195, CTBP2, TEX36, EDRF1	103	Jeong et al., 2018	Tibetans	Jeong et al., 2018