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. 2019 Aug 28;13:55. doi: 10.3389/fncir.2019.00055

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Copyright © 2019 Milinkeviciute, Henningfield, Muniak, Chokr, Green and Cramer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BLZ945 effect on the innervation of MNTB neurons and the size of the calyx of Held. (A) Percentage of polyinnervated MNTB neurons was calculated for each group. Before hearing onset, most of neurons in the MNTB were polyinnervated in both control and BLZ945-injected animals. The number of polyinnervated neurons significantly decreased at P13 in both experimental groups, but there were significantly more polyinnervated neurons remaining in microglia-depleted mice. (B) Neuronal density in AVCN and MNTB was calculated in control and microglia-depleted animals at P13 and there was no significant difference found between the two cohorts in either of the nuclei analyzed. (C) The surface area of calyces of Held was measured after 3D reconstruction of confocal z-stacks. There was no difference in surface area between control and BLZ945-treated mice at P8 or P13. In control animals, calyces grew significantly larger with age. (D) The volume of calyces of Held was also measured and was similar in control and treated animals at both ages. The volume of calyces significantly increased with age only in the control group.