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. 2019 Aug 28;13:843. doi: 10.3389/fnins.2019.00843

FIGURE 1.

FIGURE 1

Type 2 diabetes (T2D) monkeys have significantly decreased cerebrospinal fluid (CSF) Aβ40 and CSF Aβ42 concentrations, which is correlated with CSF glucose and plasma lactate concentrations. (A) plasma glucose and (B) CSF glucose concentrations were significantly elevated in T2D monkeys. (C) Plasma and CSF glucose concentrations were significantly correlated. (D) T2D monkeys had significantly decreased plasma lactate, but not (E) CSF lactate. (F) T2D monkeys had significantly decreased Aβ40, which was correlated with (G) CSF glucose and (H) plasma lactate, but not (I) plasma insulin concentrations. (J) Similarly, T2D monkeys had significantly decreased Aβ42 concentrations, which was correlated with (K) CSF glucose and (L) plasma lactate, but not (M) plasma insulin concentrations.∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; and ∗∗∗∗p < 0.0001; one-way ANOVA with Tukey’s post hoc test. Values represent mean ± SEM; solid lines represent statistically significant correlations (p < 0.05).