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. 2019 Aug 28;10:1112. doi: 10.3389/fphys.2019.01112

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Copyright © 2019 Fan, An, Wang, Chen, Liu, Liu, Ma and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential expression of circRNAs in rat hypothalamus. (A) Box plot showing the distribution of circRNA expression values in the HA and C groups. (B) Hierarchical clustering of circRNAs differentially expressed between the hypothalamus of rats in the HA and C groups; each group contained three individuals (>1.5-fold difference in expression; P < 0.05). Expression levels above and below the median expression level were indicated with different colors in all samples. (C) Volcano plots constructed using the fold changes (FCs) and P-values are shown. Vertical lines correspond to 1.5-FC in the up- and downregulation between the HA and C groups, and horizontal line indicates the P-value. The red dot in the figure indicates circRNAs with significant difference in expression. (D) Visual assessment of differences in circRNA expression between HA and C using scatter plots. The values corresponding to the x- and y-axes in the scatter plot are the normalized signals of the samples (Log2 scaled). Green lines indicate FCs. The circRNAs above the top green line and below the bottom green line show a >1.5-FCs between the HA and C groups. (E) Chromosomal distributions of differentially expressed circRNAs are shown.