Figure 9.

FX reduces NF-κB activity in THP1-Lucia™ NF-κB cells treated with LPS stimulus. THP1-Lucia™ NF-κB cells were pretreated with FX (0.03–30 μM) and then challenged with LPS (1.0 mg/L). FX showed a dose-dependent reduction in NF-κB activity in THP1-Lucia™ NF-κB cells stimulated with LPS (1.0 mg/L). Based on the logistic dose response curves, the 50% inhibitory concentration (IC₅₀) of the FX in decreasing NF-κB activity was 11.08 ± 0.78 μM. n = 5 for each treatment group. The data are representative of three independent experiments.