Figure 1. Circulating Tfh cells, Tfr cells, and Tfr/Tfh ratios in patients with pSS. (A) Gating strategies for circulating Tfh and Tfr cell populations representing CD25⁻CD127^hiCXCR5⁺CD4⁺ Tfh cells and CD25⁺CD127^loCXCR5⁺CD4⁺ Tfr cells in the peripheral blood of pSS patients (n=18) and HCs (n=14). (B) Frequencies of Tfh and Tfr cells are compared between pSS patients and HCs. (C) The Tfr/Tfh ratio is increased in pSS patients compared to HCs. Bars indicate the means±SEMs.

^*p<0.05.