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. 2019 Jul 16;19(4):e26. doi: 10.4110/in.2019.19.e26

Figure 4. Th1 and Th17 subsets of circulating Tfr cells indicate hypergammaglobulinemia in pSS. (A) Gating strategies for Th1-like, Th2-like, and Th17-like subsets of circulating Tfh and Tfr cells. (B and C) Th1-like, Th2-like, and Th17-like subsets of circulating Tfh and Tfr cells are compared between pSS patients (n=18) and HCs (n=13). Th1-like Tfh = CXCR3+CCR6− Tfh cells; Th2-like Tfh = CXCR3−CCR6− Tfh cells; Th17-like Tfh = CXCR3-CCR6+ Tfh cells; Th1-like Tfr = CXCR3+CCR6- Tfr cells; Th2-like Tfr = CXCR3-CCR6- Tfr cells; Th17-like Tfr = CXCR3-CCR6+ Tfr cells. (D) Circulating CXCR3−CCR6+ (Th17-like) Tfr cells in pSS patients with and without hypergammaglobulinemia. (E) Correlation plot of circulating Tfh and Tfr cell subsets with circulating plasmablast and plasma cell populations, serum anti-SSA/Ro Ab titers, serum RF titers, serum IgG levels, serum IL-21 levels, and the ESSDAI. (F) Correlation of circulating CXCR3+CCR6− (Th1-like) Tfr cells with serum IgG levels (n=17). (G) Correlation of circulating CXCR3-CCR6+ (Th17-like) Tfr cells with serum IgG levels (n=17). Bars indicate the means±SEMs.

Figure 4

*p<0.05; **p<0.01.