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. 2019 Aug 7;17:867–878. doi: 10.1016/j.omtn.2019.08.001

Figure 3.

Figure 3

Expression Kinetics of Low Doses of sa-RNA and pDNA after Intradermal Electroporation

(A and B) Doses from 0.5 to 0.01 μg of sa-RNA (A) or pDNA (B) were intradermally electroporated, and luciferase expression was monitored during 4 weeks by in vivo bioluminescence imaging. Only sa-RNA administrations that resulted in a successful expression are used to calculate the mean. Results are indicated as mean ± SEM of the total flux in the ROIs. Six administrations were performed. However, for the sa-RNA, not all intradermal electroporations resulted in a successful expression. The administrations that were successful are shown in (A) (n values were 4, 2, 4, and 1 for 0.5, 0.1, 0.05, and 0.01 μg sa-RNA, respectively).